The largest city in New England, Boston is considered the economic and cultural center of the region and is sometimes regarded as the unofficial "Capital of New England". Boston city proper had a 2008 estimated population of 609,023, making it the twenty-second largest in the country. Boston is also the anchor of a substantially larger metropolitan area called Greater Boston, home to 4.5 million people and the tenth-largest metropolitan area in the country.

Is an independent city and the largest city in the state of Maryland. The city is located in central Maryland along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay.

The greater Memphis metropolitan area, including adjacent counties in Mississippi and Arkansas, has a population of 1,280,533. This makes Memphis the second largest metropolitan area in Tennessee, surpassed only by metropolitan Nashville, which overtook Memphis in recent years.

Known as the world's traditional automotive center, "Detroit" is a metonym for the American automobile industry and an important source of popular music legacies celebrated by the city's two familiar nicknames, The Motor City and Motown.

The city is the nation's fourth-largest urban area by population and its fourth-largest consumer media market as ranked by the Nielsen Media Research. It is the county seat of Philadelphia County.

Phoenix is home to 1,567,924 residents, and is the anchor of the Phoenix metropolitan area, the 12th largest metro area by population in the United States with 4,281,899 residents. In addition, Phoenix is the county seat of Maricopa County, and is one of the largest cities in the United States by land area.

Chicago is the third-most densely populated major city in the U.S., and anchor to the world's 26th largest metropolitan area with over 9.5 million people across three states.